The Effects of high-intensity interval training on chronic inflammation of Lung Tissue in healthy rats

1PhD, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences,University of Mazandaran, Babolsar,Iran
2Associate Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and SportSciences,University of Mazandaran, Babolsar,Iran,
3Assistant Professor,PhD of Histological,Department of Basic Sciences,Faculty of Veterinary Medicine, University of Tabriz,Tabriz,Iran
4PhD, Department of exercise biochemitsry and metabolism,University of Mazandaran, University of Mazandaran, Babolsar,Iran
Background and Aims: Exercise training with various intensities, has different effects on the immune system response. This study investigated the effect of a period of high intensity interval training on Inflammation markers of lung tissue in healthy Wistar rats.

Methods::Twelve male Wistar rats were randomly divided into exercised (n=6) and control groups (n=6). The high intensity interval training program was carried out for 9 weeks. Training program was started with 25 m/min and ended with 70 m/min speed at the final stage. In lung tissue, expression of IL-17 was studied by the Immunohisto-chemistry, and structural changes such as macrophage population, BALT, interstitial tissue and alveolar space volume were measured by stereological assessments. independent T-test was used. P ≤ 0.05 was considered statistically significant
Results:The results showed that after the 9 weeks of high intensity interval training, the protein IL-17, macrophage population, BALT volume and interstitial space volume were increased significantly and alveolar space was significantly decreased.
Conclusions: It seems that 9 weeks of high intensity interval training program, induced chronic inflammation of the lung and defective remodeling of tissue.